Methadone (Dolophine®), Serum

Methadone (Dolophine®), Serum

Methadone (Dolophine®), Serum

For therapeutic monitoring only. Methadone possesses many of the pharmacologic properties of morphine and is approximately equipotent as an analgesic when administered parenterally. Unlike morphine, however, methadone produces marked sedative effects with repeated administration as a result of drug accumulation. This undesirable property restricted clinical usage of the drug until 1965 when Dole and Nyswander began narcotic maintenance treatment of former heroin addicts using large daily oral doses of dl-methadone. Whereas maintenance patients may receive as much as 180 mg of the drug daily, doses ¡Ü50 mg have been known to prove fatal to nontolerant adults. The pharmacologic activity is due almost entirely to the l-isomer. The d-methadone isomer does have analgesic properties in large doses and this may be due to conversion to minor amounts of alpha-l-methadone and alpha-l-normethadol, both of which are potent analgesics.

Includes: Methadone (Dolophine®), Serum

Categories: Therapeutic Drug Monitoring, Drug Screening

Price: $99.99


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